The Scarmiglione B.O.W.'s were produced in the Queen Zenobia laboratory by combining shark DNA with the T-Abyss virus. The result was a looming humanoid creature that loosely resembled a medieval knight, with a veil of tough skin draped over the head and shoulders reminiscent of chainmail. The creature's left arm has formed into a tough sheet of bone and cartilage that functions as a shield to block bullets while the right arm has formed into a long lance-like appendage for offence.
Scarmigliones will undergo one of two transformations depending on where they take the most damage:
- When damaged more in the torso and head, a Scarmiglione's upper body will explode leaving only its legs and an electric tentacle which functions like a whip. In this form, the legs will shamble themselves to the player in an attempt to shock the player with the tentacle. This form is dealt additional damage when damaged on the tentacle.
- When damaged more on the legs, the Scarmiglione's legs will explode leaving only the upper torso on the ground. In this form they will crawl on the ground, and attempt to stab the player with their lance-arm. Like in their full form, they are dealt additional damage when attacked on the head.