The MA-121 Hunter "β" was a variation of the Alpha model Hunter developed in Umbrella's Arklay Mountains facility. These new models appeared in Resident Evil 3: Nemesis.

The Beta series were created in Umbrella's underground complex in Raccoon City and ran amok during the T-virus outbreak. The experiments yielded mixed results; the Beta Hunter's left arm outgrew its right, and while their speed and reaction time was enhanced, they lacked the combat prowess of the Alphas. Another unforeseen side effect was the appearance of numerous tumour-like growths over its head and back, which obscured its vision and created weak points. Because of these mutations, the Beta Hunters were never mass-produced and were destroyed along with Raccoon City.

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