Like with other reptilian creatures, the T-virus has caused the alligator to grow in size considerably. Its mouth is large enough to snap up a human whole. Leon and Claire fought against this mutant down in Raccoon City's sewers in a tunnel connecting the sewers to the water treatment plant. The alligator was so big that its body filled up most of the width of the tunnel, making it impossible to get past the creature. The pair were able to kill the alligator after knocking over a gas canister which the creature snapped up in its mouth. Shooting the canister caused it to explode, blasting the creature's head to pieces.