In Resident Evil Zero, STARS member Rebecca Chambers and ex-Marine Billy Coen encounter a giant bat within the chapel located on the grounds of the Umbrella Research Center. This creature was an ordinary bat that had been mutated by the T-virus, causing it to grow to a tremendous size and become extremely bloodthirsty. The creature was large enough to pick up an adult human off the ground with its clawed feet and the cries it emitted could summon smaller infected bats to attack prey as a swarm. Rebecca and Billy were able to kill the creature and proceed through the facility.

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